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簡要描述：美國Mineralocorticoid（f-hMR） 人鹽皮質激素受體可誘導表達細胞株：美國PrimCells誘(you)導(dao)性(xing)穩定(ding)(ding)細胞(bao)株(zhu)： PrimCells建立(li)的*的誘(you)導(dao)性(xing)細胞(bao)高效開發系統(tong)，能在極(ji)短時間內(nei)篩選(xuan)出低泄漏，高誘(you)導(dao)性(xing)的穩定(ding)(ding)細胞(bao)株(zhu)，成功開發出一系列核受體誘(you)導(dao)表(biao)達的穩定(ding)(ding)細胞(bao)株(zhu)產品，為多家制藥公司研(yan)發部門和科(ke)研(yan)院所提供產品與服(fu)務，廣受用戶好評。針對客戶的特定(ding)(ding)需求，PrimCells亦(yi)提供量身定(ding)(ding)
產品型號：CLHKMR01廠商性(xing)質(zhi)：生產廠家 更新時間：2024-03-12訪 問 量：1207 產品分類
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美國Mineralocorticoid(f-hMR) 人鹽皮質激素受體可誘導表達細胞株
美國PrimCells誘(you)導(dao)性穩(wen)定細胞株(zhu)： PrimCells建立的*的誘(you)導(dao)性細胞高效開(kai)發系統，能在(zai)(zai)極(ji)短(duan)時間內篩選(xuan)出低(di)泄漏(lou)，高誘(you)導(dao)性的穩(wen)定細胞株(zhu)，成(cheng)功開(kai)發出一系列(lie)核受(shou)體誘(you)導(dao)表達的穩(wen)定細胞株(zhu)產品(pin)，為多家制(zhi)藥公司研發部門和科研院所提供產品(pin)與(yu)服務，廣受(shou)用(yong)戶好評(ping)。針對客(ke)(ke)戶的特定需求，PrimCells亦提供量身定制(zhi)服務，通過密切的客(ke)(ke)戶交(jiao)流和高效的篩選(xuan)體系，嚴格保證客(ke)(ke)戶在(zai)(zai)3-4周(zhou)內即獲得(de)高質量的誘(you)導(dao)性穩(wen)定細胞株(zhu)，具有市(shi)場其他(ta)供應商*的時效性。
Introduction:
Nuclear hormone receptors (NHRs) are a superfamily of transcription factors that function as powerful metabolic regulators to control a variety of systemic processes in physiology. They also play key roles in the pathophysiology of many major disease states, such as diabetes, obesity, inflammation, atherosclerosis and heart failure. To date, this superfamily has provided a rich source of drug design targets and it is continuing to be one of the hottest areas for pharmaceutical research. PrimCells now provides a comprehensive set of NHR expressing cell lines to the research community. These high-quality, flag- and/or HA-tagged NHR-expressing cell lines aim to facilitate further biochemical and molecular studies of their functions and hence encourage new strategies for drug design.
f-hMR/HEK293 cell line was created by stable co-transfection of HEK293 cells with two plasmids expressing the bacterial Tet repressor (TetR) and the human mineralocorticoid receptor (hMR) proteins. Since the hMR gene is driven by a promoter containing two tetracycline operator (TeTO2) sites, the expression of hMR protein can be induced by doxycycline.
美國Mineralocorticoid(f-hMR) 人鹽皮質激素受體可誘導表達細胞株
Figure 1 | Confirmed hMR Expression in f-hMR stable cells
美國(guo)PrimCells品牌(pai)介紹
PrimCells是位于美國加州圣迭(die)戈的一(yi)家專業(ye)致(zhi)力于細胞產品研(yan)發和解決方案提(ti)供的業(ye)內(nei)技術。
公(gong)司(si)匯集(ji)了資深的生物醫藥技術專家(jia)，獨立(li)開發了多(duo)(duo)項(xiang)原(yuan)代細胞(bao)(bao)和(he)干細胞(bao)(bao)相關的專有技術。 公(gong)司(si)以“細胞(bao)(bao)研(yan)究(jiu)的優選擇"為(wei)宗旨，自主(zhu)研(yan)發超(chao)過70種創(chuang)新產品(pin)，多(duo)(duo)個特種細胞(bao)(bao)市(shi)場(chang)的空白。例如(ru)其(qi)誘(you)導性(xing)表達細胞(bao)(bao)庫和(he)高效3D皮膚培養系(xi)統，皆為(wei)該類(lei)產品(pin)目(mu)前市(shi)場(chang)上少數(shu)的規模化(hua)供(gong)應商。此(ci)外，公(gong)司(si)以高質量(liang)的數(shu)據與快速穩定(ding)的項(xiang)目(mu)完成(cheng)時間，長期為(wei)多(duo)(duo)家(jia)制(zhi)藥公(gong)司(si)提供(gong)解決方案，獲得用戶廣泛贊譽。
PrimCells產品線：
報告基(ji)(ji)因(yin)干細(xi)胞(bao) 2. 原(yuan)代細(xi)胞(bao)（含報告基(ji)(ji)因(yin)原(yuan)代細(xi)胞(bao)） 3. 誘(you)導性穩定細(xi)胞(bao)株
4. 人源(yuan)重組蛋白 5. 創新型培養試劑
PrimCells 解決方案
1.誘導性(xing)穩定細(xi)胞株開(kai)發(fa) 2. 原代細(xi)胞開(kai)發(fa) 3. 藥物體外毒理和效(xiao)能(neng)測試(shi) 4. 3D-皮膚培養(yang)
PrimCells合作伙伴及客戶(hu):
A．生物制藥(yao)公(gong)司(si)：輝瑞(Pfizer), 諾華(Novartis), 禮(li)來(lai)(Eli2 Lilly),. Amgen, EMD Millipore, Regeneron等公(gong)司(si)的毒理和醫藥(yao)研(yan)發部門
B．科研機構(gou)：冷泉港實驗室(shi)，哈佛(fo)醫(yi)學院, 麻(ma)省理工（MIT）,， UCSF, NYU, Salk, UIUC, USC等
美國Mineralocorticoid(f-hMR) 人鹽皮質激素受體可誘導表達細胞株
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