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簡要描述：美國人Glucocorticoid糖皮質激素受體穩定細胞株（線粒體表達）美國人糖皮質激素受體穩定細胞株美國(guo)PrimCells誘(you)(you)導(dao)性(xing)穩(wen)定細胞(bao)株(zhu)： PrimCells建立的(de)*的(de)誘(you)(you)導(dao)性(xing)細胞(bao)高效開發(fa)系統，能在極(ji)短時間內(nei)篩(shai)選出低(di)泄漏(lou)，高誘(you)(you)導(dao)性(xing)的(de)穩(wen)定細胞(bao)株(zhu)，成(cheng)功開發(fa)出一系列核受體(ti)誘(you)(you)導(dao)表達的(de)穩(wen)定細胞(bao)
產品型號：CLHKGR02廠商性質：生產廠家 更新時間：2024-03-12訪 問 量：1381 產品分類
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美國人Glucocorticoid糖皮質激素受體穩定細胞株（線粒體表達）
美(mei)國PrimCells誘(you)導性穩(wen)定(ding)細(xi)胞(bao)株： PrimCells建立(li)的(de)(de)*的(de)(de)誘(you)導性細(xi)胞(bao)高效(xiao)開發系統(tong)，能(neng)在(zai)極短時間內篩選出低泄漏，高誘(you)導性的(de)(de)穩(wen)定(ding)細(xi)胞(bao)株，成功開發出一系列核受(shou)體誘(you)導表達的(de)(de)穩(wen)定(ding)細(xi)胞(bao)株產(chan)(chan)品(pin)，為多(duo)家制(zhi)(zhi)藥公司研發部門(men)和科研院所提(ti)供產(chan)(chan)品(pin)與服務，廣受(shou)用戶(hu)好評(ping)。針對客戶(hu)的(de)(de)特(te)定(ding)需求(qiu)，PrimCells亦提(ti)供量身(shen)定(ding)制(zhi)(zhi)服務，通過密切的(de)(de)客戶(hu)交流(liu)和高效(xiao)的(de)(de)篩選體系，嚴(yan)格(ge)保證客戶(hu)在(zai)3-4周內即獲得高質量的(de)(de)誘(you)導性穩(wen)定(ding)細(xi)胞(bao)株，具有市(shi)場其他(ta)供應商*的(de)(de)時效(xiao)性。
美國人Glucocorticoid糖皮質激素受體穩定細胞株（線粒體表達）
Introduction:
Nuclear hormone receptors (NHRs) are a superfamily of transcription factors that function as powerful metabolic regulators to control a variety of systemic processes in physiology. They also play key roles in the pathophysiology of many major disease states, such as diabetes, obesity, inflammation, atherosclerosis and heart failure. To date, this superfamily has provided a rich source of drug design targets and it is continuing to be one of the hottest areas for pharmaceutical research.
PrimCells now provides a comprehensive set of NHR expressing cell lines to the research community. These high-quality, Flag and/or HA-tagged NHR-expressing cell lines aim to facilitate further biochemical and molecular studies of their functions and hence encourage new strategies for drug design.
Glucocorticoids (GCs) are steroid hormones that allow us to cope with environmental and physiological stresses. Although GCs are widely used as anti-inflammatory agents in several clinical areas, long-term use of those steroids causes problems instead. Full achievement of the clinical potential of GCs necessitates limiting the side effects of these drugs.
The lipophilic nature of GCs allows them to readily diffuse into the cells, where they bind to a cytosolic receptor, the Glucocorticoid Recetpor (GR) to exert their mechanism of action. Without ligand binding, GR is predominantly localized in cytoplasm, whereas upon ligand binding it rapidly translocates to nucleus where it can both positively and negatively regulate gene expression. GR belongs to the nuclear receptor superfamily of ligand-activated transcription factors that function as powerful metabolic regulators. Several studies have shown that GR also translocates to the mitochondrial in addition to its nuclear translocation in response to GC treatment. The mitochondrial GR translocation has been shown to be positively correlated with GC-induced apoptosis, although the mechanism is unclear.
The mitochondrial-specific GR (Flag and HA tagged)/HEK293 cell line was created by stable transfection of HEK293 cells with a plasmid expressing Flag and HA tagged GR protein with a mitochondrial localization signal.
美國(guo)PrimCells品牌介紹(shao)
PrimCells是位(wei)于美國加州(zhou)圣迭(die)戈的一家專業致力(li)于細胞產品研發和解決方案(an)提供的業內(nei)技術。
公(gong)司匯(hui)集了資(zi)深的(de)(de)生物醫藥技術(shu)專(zhuan)家(jia)，獨(du)立開(kai)發了多(duo)項原代細(xi)胞和(he)干(gan)細(xi)胞相關的(de)(de)專(zhuan)有技術(shu)。 公(gong)司以“細(xi)胞研(yan)究的(de)(de)優選(xuan)擇"為宗(zong)旨(zhi)，自主研(yan)發超(chao)過70種創新產品(pin)，多(duo)個特種細(xi)胞市(shi)場的(de)(de)空白。例如其誘導性表達細(xi)胞庫和(he)高(gao)效3D皮膚培養系統(tong)，皆(jie)為該類(lei)產品(pin)目前市(shi)場上(shang)少數的(de)(de)規模化供(gong)應商。此外，公(gong)司以高(gao)質量的(de)(de)數據與快速穩(wen)定的(de)(de)項目完成時間，長期為多(duo)家(jia)制(zhi)藥公(gong)司提供(gong)解決方案，獲得用戶廣(guang)泛贊譽。
PrimCells產品線：
報(bao)告(gao)基因干細(xi)(xi)(xi)胞(bao)(bao) 2. 原代(dai)細(xi)(xi)(xi)胞(bao)(bao)（含(han)報(bao)告(gao)基因原代(dai)細(xi)(xi)(xi)胞(bao)(bao)） 3. 誘導性穩定細(xi)(xi)(xi)胞(bao)(bao)株
4. 人源重(zhong)組蛋白(bai) 5. 創新型培養試(shi)劑
PrimCells 解(jie)決方案
1.誘導性穩定細胞株開發 2. 原代細胞開發 3. 藥物體外毒理(li)和(he)效(xiao)能測(ce)試(shi) 4. 3D-皮膚培養
PrimCells合作伙伴及客(ke)戶:
A．生物制藥公(gong)(gong)司：輝瑞(rui)(Pfizer), 諾華(Novartis), 禮(li)來(Eli2 Lilly),. Amgen, EMD Millipore, Regeneron等公(gong)(gong)司的毒理和醫藥研(yan)發部門
B．科(ke)研機構(gou)：冷泉(quan)港實驗(yan)室，哈佛醫(yi)學院, 麻省理工(gong)（MIT）,， UCSF, NYU, Salk, UIUC, USC等
美國人Glucocorticoid糖皮質激素受體穩定細胞株（線粒體表達）
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