簡要描述:(VDR) : PrimCells建立(li)的(de)(de)*的(de)(de)誘導(dao)性細胞(bao)高(gao)(gao)效開發(fa)系統,能在極短時間內(nei)篩選出低泄漏(lou),高(gao)(gao)誘導(dao)性的(de)(de)穩(wen)定細胞(bao)株,成功開發(fa)出一系列核受體誘導(dao)表達(da)的(de)(de)穩(wen)定細胞(bao)株產品,為多家(jia)制藥公司研發(fa)部門和科(ke)研院所提供產品與服務(wu),廣受用(yong)戶(hu)好評。針對客(ke)戶(hu)的(de)(de)特定需求(qiu),PrimCells亦
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美國Human VitaminD receptor (VDR) 人受體可誘導表達穩定細胞株
美國PrimCells誘導性(xing)穩(wen)定(ding)細(xi)(xi)胞(bao)株: PrimCells建(jian)立(li)的(de)(de)(de)(de)*的(de)(de)(de)(de)誘導性(xing)細(xi)(xi)胞(bao)高(gao)(gao)效開發(fa)(fa)系統,能在極短時(shi)間內篩選(xuan)出低泄漏,高(gao)(gao)誘導性(xing)的(de)(de)(de)(de)穩(wen)定(ding)細(xi)(xi)胞(bao)株,成功(gong)開發(fa)(fa)出一系列核受(shou)體(ti)誘導表達的(de)(de)(de)(de)穩(wen)定(ding)細(xi)(xi)胞(bao)株產(chan)品,為(wei)多家制藥公司(si)研發(fa)(fa)部門和科研院所(suo)提供(gong)產(chan)品與服務(wu),廣(guang)受(shou)用(yong)戶好評。針對客(ke)戶的(de)(de)(de)(de)特定(ding)需求,PrimCells亦提供(gong)量(liang)身定(ding)制服務(wu),通過密切(qie)的(de)(de)(de)(de)客(ke)戶交(jiao)流和高(gao)(gao)效的(de)(de)(de)(de)篩選(xuan)體(ti)系,嚴格保證客(ke)戶在3-4周內即獲得高(gao)(gao)質(zhi)量(liang)的(de)(de)(de)(de)誘導性(xing)穩(wen)定(ding)細(xi)(xi)胞(bao)株,具有市場其(qi)他供(gong)應商*的(de)(de)(de)(de)時(shi)效性(xing)。
美國Human VitaminD receptor (VDR) 受體可誘導表達穩定細胞株
Nuclear hormone receptors (NHRs) are a superfamily of transcription factors that function as powerful metabolic regulators to control a variety of systemic processes in physiology. They also play key roles in the pathophysiology of many major disease states, such as diabetes, obesity, inflammation, atherosclerosis and heart failure. To date, this superfamily has provided a rich source of drug design targets and it is continuing to be one of the hottest areas for pharmaceutical researches.
PrimCells now provides a comprehensive set of NHR expressing cell lines to the research community. These high-quality, flag-and/or HA-tagged NHR-expressing cell lines aim to facilitate further biochemical and molecular studies of their functions and hence encourage new strategies for drug design.
The human VDR stable cell line was created by stable co-transfection of HEK293 cells with two plasmids expressing the bacterial Tet repressor (TetR) and the human VDR protein with HA tag, respectively. Since the human VDR gene is driven by a promoter containing two tetracycline operator (TeTO2) sites, its expression can be induced by doxycycline.
美國PrimCells品牌介紹(shao)
PrimCells是位于美(mei)國(guo)加州(zhou)圣迭戈的一家專業(ye)致(zhi)力于細胞產品研(yan)發和解決方(fang)案提供的業(ye)內技術。
公(gong)司(si)匯集(ji)了(le)資深的(de)(de)生物(wu)醫藥(yao)技術專家(jia),獨立開發了(le)多(duo)(duo)項原代細(xi)(xi)胞和干細(xi)(xi)胞相關的(de)(de)專有技術。 公(gong)司(si)以“細(xi)(xi)胞研究的(de)(de)優選擇(ze)"為(wei)宗旨,自主研發超過70種創新產品,特(te)種細(xi)(xi)胞市場(chang)的(de)(de)空(kong)白。例如其(qi)誘導性表達細(xi)(xi)胞庫和高效3D皮膚培養(yang)系統,皆為(wei)該類產品目前市場(chang)上(shang)少數(shu)的(de)(de)規模(mo)化供(gong)應商。此(ci)外,公(gong)司(si)以高質量的(de)(de)數(shu)據與快速穩定(ding)的(de)(de)項目完成時間,長(chang)期為(wei)多(duo)(duo)家(jia)制藥(yao)公(gong)司(si)提供(gong)解決(jue)方(fang)案,獲得用戶廣(guang)泛(fan)贊譽。
PrimCells產(chan)品線:
報告基(ji)因干細(xi)胞 2. 原代細(xi)胞(含報告基(ji)因原代細(xi)胞) 3. 誘導(dao)性穩定細(xi)胞株(zhu)
4. 人源重組蛋白 5. 創新(xin)型培養試劑
PrimCells 解決方案
1.誘導(dao)性穩定細(xi)胞株(zhu)開(kai)發 2. 原代細(xi)胞開(kai)發 3. 藥(yao)物(wu)體外毒(du)理和效能測試 4. 3D-皮膚培養
PrimCells合作伙(huo)伴及客戶:
A.生物制藥公(gong)司:輝(hui)瑞(rui)(Pfizer), 諾華(hua)(Novartis), 禮來(Eli2 Lilly),. Amgen, EMD Millipore, Regeneron等公(gong)司的毒理和醫(yi)藥研發部門
B.科研機構:冷(leng)泉港實(shi)驗室,哈佛醫(yi)學院, 麻省理工(MIT),, UCSF, NYU, Salk, UIUC, USC等
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